ANTI-ACNE EFFECT OF FLAVONOIDS AND POLYPHENOLS, ANTI-AGING EFFECTS OF FLAVONOIDS & POLYPHENOLS, ANTI-CANCER EFFECTS OF FLAVONOIDS & POLYPHENOLS, ANTI-INFLAMMATORY EFFECTS OF FLAVONOIDS & POLYPHENOLS, ANTI-VIRAL EFFECTS OF FLAVONOIDS & POLYPHENOLS, FASTING, CALORIE RESTRICTION & EXTENDING LIFESPAN, JNK ACTIVATION PREVENTS PREMATURE SENESCENCE, NRF2: MASTER REGULATOR OF THE AGING PROCESS, SENESCENCE-BETA-GALACTOSIDASE (SA-β-gal or SABG), INTERSTELLAR 88/8: EXTREME WEIGHTLOSS PROTOCOL, Anti-Acne effect of Flavonoids and Polyphenols. The plant stems were soaked in dichloromethane (DCM) solution while three batches of rubber trees that consist of five trees were prepared. B., Krishna, V. and Hoskeri, H. J. It produces attractive bushy foliage that is covered by an often profuse bloom of phlox-like flowers from summer to frost. Herbal use in the Caribbean includes using extracts from the flowers as an eyewash for infants. Scientists discovered the presence of several highly toxic alkaloids in the tissues of C roseus, while researching the anti-diabetic properties of the plant. According to Zaini and Halimoon (2013), Catharanthus roseus is regarded as a poisonous plant because of the presence of danvinrosidin, catharanthine, vindolinine, leurosine, akuammine, norharman, lochnerine, vinleurosin, tetrahydroalstonine, vindoline and vincamine in it. Zaini and Halimoon (2013) reported that the white root disease caused by the Rigidoporus Microporus fungus are the most destructive disease found in a rubber plantation. Piperazine citrate was used as the standard reference. The ethanol extract of this plant also demonstrated to be more effective than the standard drug. One of such medicinal plants that have received global recognition due to its exceptional benefits is Catharanthus roseus. Decoctions of the plant have been used to treat ocular inflammation, diabetes, hemorrhages, insect stings, and cancers.2, 4, 5, 6, 7 Sadabahar also known as Madagascar Periwinkle, “Sada Pushpa” belongs to the Apocynaceae family.It is called botanically as Catharanthus roseus. Vinca Rosea plant got it’s name because it originally originated in Madagascar and many other species of Vinca Rosea are found only in Madagascar. However, the dose of 1 mL/kg did not only counteracted the elevation, but also significantly (p < 0.05) reduced the serum level LDL-c and the ratio of total cholesterol and HDL-c. Based on the numerous amazing benefits of plants, it is quite logical to witness why there is a growing interest in medicinal plants all over the world. Other plants for treating dementia can be found here.Anti-cancer PropertiesAccording to Jaleel et al., (2009) the anticancer alkaloids (vinblastine and vincristine) found in the leaf and stem of Catharanthus roseus inhibits cancer and tumour cells in the body. Synergistic and cytotoxic action of indole alkaloids produced from elicited cell cultures of Catharanthus roseus. Therefore the results show that the ethanol extract of Catharanthus roseus has significant anthelmintic properties against Pheretima posthuma. Botanical Name: Cantharanthus roseus In adult Hodgkin’s lymphoma, the Catharanthus. Vincamine is a natural vasodilator, which means that it increases blood flow and oxygen supply to the brain. Many of the vinca alkaloids were first isolated from Catharanthus roseus, including vinblastine and vincristine used in the treatment of leukemia and Hodgkin's lymphoma. 9. 0. The vinca alkaloids impede all fast-dividing cell types including cancer cells. British Journal of Pharmacology and Toxicology, 1(1): 40-44. 68 No. They also help to increase the levels of serotonin (a compound found in serum and blood platelets that contracts the blood vessels and acts as a neurotransmitter) in the brain.Biofungicide PropertiesBiofungicides are preparations of living organisms that are used for controlling and destroying the activity of plant pathogenic fungi and bacteria. There are several ways you can get this benefit from the periwinkle flowers. British Journal of Pharmacology and Toxicology, 1(1): 40-44.12] Quideau, S. Deffieux D., Douat-Casassus C. and Pouysegu L. (2011), Plant polyphenols: chemical properties, biological activities, and synthesis. These were assessed for DPPH (diphenylpicrylhydrazyl) radical scavenging activity. Medicinal Uses Of Periwinkle Plant B. Sharangi}, journal={Journal of Pharmacognosy and … Indian Ayurvedic medicine and other traditional herbal systems use Catharanthus roseus for the treatment of diabetes. Interestingly, most of these medicinal plants are capable of attacking fungal, bacterial and viral infections. Neuropsychobiology, 34(1), pp. The leaves demonstrated good antioxidant effects of 81.70%. ~ In Madagascar, the leaves are used as vomitive (inducing vomiting), the roots are used as purgative, anthelmintic (for expelling worms), hemostatic (causes bleeding to stop) and for stopping toothache. According to Ethalsha and Retna (2014), periwinkle contains more than 400 alkaloids of which some have been categorised as antineoplastic agents for inhibiting or preventing the growth and spread of tumours or malignant cells such as rhabdomyosarcoma, leukaemia, neuroblastoma, malignant lymphomas and Hodgkin's disease. In parts of Central America, it is made into a gargle for sore throats. The ethanol extract of this plant also demonstrated to be more effective than the standard drug. Botanical : Catharanthus roseus . The antimicrobial activity was also checked against microorganisms such as Salmonella typhimurium NCIM 2501, Pseudomonas aeruginosa NCIM 2036 and Staphylococcus aureus NCIM 5021. It is noted for attracting wildlife. 13] Jaleel, C. A., Gopi, R. and Paneerselvam, R. (2009), Alterations in non-enzymatic antioxidant components of Catharanthus roseus exposed to paclobutrazol, gibberellic acid and Pseudomonas fluorescens, Plant Omics Journal, 2: 30-40. 29-35. The plant is originally from the Caribbean Basin, West Indies and Madagascar before spreading to other parts of the world such as Africa, Australia, Southern Europe and India where it is mostly grown for commercial purposes due to its high medicinal and ornamental benefits. Aminul Ahsan, Shamim Ahmed, Md. Ethalsha and Retna (2014) examined the antibacterial properties of the crude extracts obtained from the roots of Catharanthus roseus against several bacterial species of clinical significance. The results were compared with the standard drug glibenclamide (5 mg/kg body weight) by measuring the glucose levels and the body weights of all the study animals. 10] Patharajan, S. and Abirami, S. A. The examination was carried out using paper disc diffusion method whereby 3 extraction media (acetone, aqueous and ethanol) were used. Despite serious safety concerns, periwinkle is used for “brain health” (increasing blood circulation in the brain, supporting brain metabolism, increasing mental productivity, preventing memory and concentration problems and feebleness, improving memory and thinking ability, and preventing early aging of brain cells). Despite serious safety concerns, Madagascar periwinkle is used for diabetes, cancer, and sore throat.It is also used as a cough remedy, for easing lung congestion, and to reduce fluid retention by increasing urine production (as a diuretic).. 1] Agarwal, S., Jacob, S., Chettri, N., Bisoyi, S., Tazeen, A., Vedamurthy, A. Thus the C roseus plant ensures brain health. It is small in size perennial herbaceous evergreen plant that was native to the Madagascar island. Despite serious safety … Other herbs for treating diabetes can be found here. We pledge to keep your email safe. Other traditional herbal treatments include using the plant for … The Gram-positive bacteria were found more sensitive than the Gram-negative bacteria. Vinblastine is mostly sold as Velban. Anti diabetic - Catharanthus roseus is a medicinal plant belonging to the family Apocynaceae which produces terpenoid indole alkaloids (TIAs) of high medicinal importance. The parts that grow above the ground are used to make medicine. Nat Prod 50:586–621. 1-4. Join me on this journey to discover, share and grow knowledge on recipes for life from around the globe. Despite serious safety concerns, periwinkle is used for “brain health” (increasing blood circulation in the brain, supporting brain metabolism, increasing mental productivity, preventing memory and concentration problems and feebleness, improving memory and thinking ability, and preventing early aging of brain … Don't confuse periwinkle with Madagascar periwinkle (Catharanthus roseus). The fact still remains that most plants offer medicinal supports to tackle several ailments that tend to pose dangers to human beings. Some of the health benefits of Sadabahar, periwinkle, or the Catharanthus roseusplant are: The leaves and stems are a source of alkaloids that have anti-tumor and anti-cancer properties. C. roseus is an amazing chemical factory, producing more than 130 TIAs, some of which exhibit strong pharmacological activities. List of various diseases cured by Catharanthus Roseus. Serum lipid profile (total cholesterol, triglycerides, LDL-c, VLDL-c, HDL-c) was performed in each of the animals groups before and at the end of the six weeks trial. Catharanthus roseus (Vinca) also known as the Madagascar periwinkle or rosy periwinkle or Sadabahar is grown as an ornamental plant in the garden. The leaves contain cartharanthine, leurosin, 21-oxo-leurosine, catharanthamine, coronaridine, vindoline, vimblastine, leurosidine, vincristine, tetrhydrolastonine, lochnerine, vincarodine, - Nboxide and pericylivine as reported by Cordell (2001). 2] Aruna, M. S., Prabha, M. S., Priya, N. S. and Nadendla, R. (2015),Catharanthus roseus: Ornamental plant is now medicinal boutique, Journal of Drug Delivery & Therapeutics, 5(3), pp. (adsbygoogle = window.adsbygoogle || []).push({});These researchers carried out a study in other to ascertain if the stems extract from kemunting cina can control white root disease of rubber trees as well as to observe the plants performance towards the fungus. G. Donn. Studies reveal that most of the vinca alkaloids were first isolated from Catharanthus roseus. The oval, hairless, greenish leaves are glossy in appearance with a short petiole that measures between 1 to 1.8 centimetres long. The stem extracts of kemunting cina were antagonistic and inhibited the Rigidoporus microporus fungus. (2014), Antioxidant activity and phytochemical analysis of fractionated leaf extracts of Catharanthus roseus, International Journal of Pharmacognosy, vol. They also help to increase the levels of serotonin (a compound found in serum and blood platelets that contracts the blood vessels and acts as a neurotransmitter) in the brain. Catharanthus roseus, commonly called periwinkle, Madagascar periwinkle or annual vinca, is an erect to spreading tender perennial in the dogbane family typically mounding 6-18” (less frequently to 24”) tall and as wide.It produces attractive bushy foliage that is covered by an often profuse bloom of phlox-like flowers from summer to frost. These treated rats recorded high rate of wound contraction that significantly reduced the epithelization (process of covering a denuded surface with epithelium) period. The vinca bis-indole alkaloids, isolated from Catharanthus roseus, include naturally occurring vinblastine 1 and vincristine 2. Nayak et al., (2007) carried out an experiment where rats were treated with 100 mg /kg/day of the Catharanthus roseus ethanol extract. Catharanthus roseus (C. roseus) is an important medicinal plant distributed in many countries. Therefore the results show that the ethanol extract of Catharanthus roseus has significant anthelmintic properties against Pheretima posthuma. HI THERE.. 8] Ibrahim, M., SughraMehjabeen, S. and Narsu, M. L. (2011), Pharmacological evaluation of Catharanthus roseus, International Journal of Pharmaceutical Applications ISSN 0976-2639. DISCLAIMER This post is for enlightenment purposes only and should not be used as a replacement for professional diagnosis and treatments. Suitable for: light (sandy), medium (loamy) and heavy (clay) soils, prefers well-drained soil and can grow in nutritionally poor soil. Fischhof et al., (1996) investigated the therapeutic effects of vincamine for treating primary degenerative and vascular dementia. As an herb, Catharanthus roseus is well known around the world according to the National Tropical Botanical Garden. This suggests why vinblastine is used for treating neoplasms (a new and abnormal growth of tissue in the body parts) choriocarcinoma (a fast-growing type of cancer that occurs in a woman's uterus (womb) and Hodgkin’s disease (painless enlargement of the lymph nodes, liver, and spleen). The plant stems were soaked in dichloromethane (DCM) solution while three batches of rubber trees that consist of five trees were prepared. To. Catharanthus roseus is an evergreen Perennial growing to 0.7 m (2ft 4in) by 0.7 m (2ft 4in) at a fast rate. Studies reveal that rose periwinkle contains vasodilating (widening of blood vessels) and memory-enhancing properties, which help to tackle vascular dementia and Alzheimer's disease. Antifungal PropertiesKumari and Gupta (2013) examined the antifungal properties of Catharanthus roseus against several clinically significant fungal strains namely; Fusarium moniliforme, Candida albicans, Aspergillus niger and Aspergillus fumigatus. The therapeutic efficacy of vincamine was evidenced by the confirmatory analysis because the drug was statistically significantly superior to placebo in all the four target variables. (2011), Evaluation os Hypolipidemic activity of leaf juice of Catharanthus roseus (Linn.) • Vincristine / Anticancer Ingredient: Vincristine is a dimer-indo-akaloid from the leaves of C. roseus, used in the treatment of acute lymphocytic cell leukemia, Hodgkin's disease and non-Hodgkin disease. Vincristine is mostly sold as oncovin. These daily supplements have also been deemed effective for preventing and inhibiting the abnormal coagulation of blood in the brain. After the periwinkle was introduced to the southern United States, it has now become an ornamental plant grown in flowerbeds, serving as a great boarder plant. 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